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Article

PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress

1 Dec 2016

Abstract excerpt

Maintaining genomic integrity during DNA replication is essential for cellular survival and for preventing tumorigenesis. Proliferating cell nuclear antigen (PCNA) functions as a processivity factor for DNA replication, and posttranslational modification of PCNA plays a key role in coordinating DNA repair against replication-blocking lesions by providing a platform to recruit factors required for DNA repair and...

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PMID: 27906959
DOI: 10.1371/journal.pgen.1006465

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