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Article

RNAPII-dependent ATM signaling at collisions with replication forks.

Nature communications - 24 Aug 2023

Einig Elias, Jin Chao, Andrioletti Valentina, Macek Boris, Popov Nikita

Abstract excerpt

Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and are thought to underlie genomic instability in tumor cells. Here we provide evidence that elongating RNAPII nucleates activation of the ATM kinase at TRCs to stimulate DNA repair. We show the ATPase WRNIP1...

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Identifiers

PMID: 37620345
DOI: 10.1038/s41467-023-40924-4
PMCID: PMC10449895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNAPII-dependent ATM signaling at collisions with replication forks.PMID 37620345Read ↗

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