Article
Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.
Physiological genomics - 1 Feb 2020
Mesa Ana M, Mao Jiude, Nanjappa Manjunatha K, Medrano Theresa I, Tevosian Sergei, Yu Fahong, Kinkade Jessica, Lyu Zhen, Liu Yang, Joshi Trupti, Wang Duolin, Rosenfeld Cheryl S, Cooke Paul S
Abstract excerpt
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that suppresses gene expression. Previously, we developed a conditional null model where EZH2 is knocked out in uterus. Deletion of uterine EZH2 increased proliferation of luminal and glandular epithelial cells. Herein, we used RNA-Seq in wild-type (WT) and EZH2 conditional knockout (Ezh2cKO) uteri to obtain mechanistic insights into the gene...
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