Article
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development.
Development (Cambridge, England) - 1 Sept 2003
Erhardt Sylvia, Su I-Hsin, Schneider Robert, Barton Sheila, Bannister Andrew J, Perez-Burgos Laura, Jenuwein Thomas, Kouzarides Tony, Tarakhovsky Alexander, Surani M Azim
Abstract excerpt
Enhancer of zeste 2 (Ezh2), a SET domain-containing protein, is crucial for development in many model organisms, including early mouse development. In mice, Ezh2 is detected as a maternally inherited protein in the oocyte but its function at the onset of development is unknown. We have used a conditional allele of Ezh2 to deplete the oocyte of this maternal inheritance. We show that the loss of maternal Ezh2 has...
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