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Article

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

1 Nov 2011

Abstract excerpt

Polycomb-group (PcG) proteins are essential regulators of hematopoietic stem cells (HSCs). In contrast to Bmi1, a component of Polycomb repressive complex 1 (PRC1), the role of PRC2 and its components in hematopoiesis remains elusive. Here we show that Ezh2, a core component of PRC2, is essential for fetal, but not adult, HSCs. Ezh2-deficient embryos died of anemia because of insufficient expansion of...

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Share to Epigenetics and DNA Methylation
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PMID: 22042701
DOI: 10.1182/blood-2011-03-340554

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