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Article

Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures.

Retrovirology - 3 May 2016

Antell Gregory C, Dampier Will, Aiamkitsumrit Benjamas, Nonnemacher Michael R, Jacobson Jeffrey M, Pirrone Vanessa, Zhong Wen, Kercher Katherine, Passic Shendra, Williams Jean W, Schwartz Gregory, Hershberg Uri, Krebs Fred C, Wigdahl Brian

Abstract excerpt

BACKGROUND: HIV-1 entry is a receptor-mediated process directed by the interaction of the viral envelope with the host cell CD4 molecule and one of two co-receptors, CCR5 or CXCR4. The amino acid sequence of the third variable (V3) loop of the HIV-1 envelope is highly predictive of co-receptor utilization preference during entry, and machine learning predictive algorithms have been developed to characterize...

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Topics

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Share to CD4 Antigens
Share to HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Long Terminal Repeat

Share to Peptide Fragments

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 27143130
DOI: 10.1186/s12977-016-0266-9
PMCID: PMC4855882

Genes

CCR5
CXCR4
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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