Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotype variation in human immunodeficiency virus type 1 transmission and disease progression.

Disease markers - 1 Jan 2009

Cavarelli Mariangela, Scarlatti Gabriella

Abstract excerpt

Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly CCR5 and CXCR4. Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. Thus, R5 and X4 virus use respectively CCR5 and CXCR4, whereas R5X4 virus can use either CCR5 or CXCR4. This review describes the central role played...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to CCR5 gene
Share to CXCR4 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 19893208
DOI: 10.3233/DMA-2009-0656
PMCID: PMC3834669

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype variation in human immunodeficiency virus type 1 transmission and disease progression.PMID 19893208Read ↗

Pathogenesis of HIV infectionSemantic proximity Read ↗

Evolution driven by a varying host environment selects for distinct HIV-1 entry phenotypes and other informative variantsSemantic proximity Read ↗

The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Determination of co-receptor usage of HIV-1.Semantic proximity Read ↗

HIV tropism: diagnostic tools and implications for disease progression and treatment with entry inhibitorsSemantic proximity Read ↗

Correlation of coreceptor usage and disease progressionSemantic proximity Read ↗

HIV co-receptor-tropism: cellular and molecular events behind the enigmatic co-receptor switchingSemantic proximity Read ↗

HIV-1 co-receptor usage: influence on mother-to-child transmission and pediatric infection.Semantic proximity Read ↗

HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes.Semantic proximity Read ↗

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.Semantic proximity Read ↗

Asymmetric HIV-1 co-receptor use and replication in CD4(+) T lymphocytes.Semantic proximity Read ↗

Rapid CD4 cell loss is caused by specific CRF01_AE cluster with V3 signatures favoring CXCR4 usageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.