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Prediction of Co-Receptor Usage of HIV-1 from Genotype

15 Apr 2010

Abstract excerpt

Human Immunodeficiency Virus 1 uses for entry into host cells a receptor (CD4) and one of two co-receptors (CCR5 or CXCR4). Recently, a new class of antiretroviral drugs has entered clinical practice that specifically bind to the co-receptor CCR5, and thus inhibit virus entry. Accurate prediction of the co-receptor used by the virus in the patient is important as it allows for personalized selection of effective...

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PMID: 20419152
DOI: 10.1371/journal.pcbi.1000743

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