Article
HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis.
AIDS research and therapy - 7 Feb 2020
Matume Nontokozo D, Tebit Denis M, Bessong Pascal O
Abstract excerpt
BACKGROUND: Entry inhibitors, such as Maraviroc, hold promise as components of HIV treatment and/or pre-exposure prophylaxis in Africa. Maraviroc inhibits the interaction between HIV Envelope gp120 V3-loop and CCR5 coreceptor. HIV-1 subtype C (HIV-1-C) is predominant in Southern Africa and preferably uses CCR5 co-receptor. Therefore, a significant proportion of HIV-1-C CXCR4 utilizing viruses (X4) may compromise...
Topics
- Drug Resistance, Multiple, Viral
- Genotype
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Maraviroc
- Phylogeny
- Receptors, CXCR4
- Receptors, HIV
- Sequence Analysis, DNA