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Article

Complex positive selection pressures drive the evolution of HIV-1 with different co-receptor tropisms.

Science China. Life sciences - 1 Oct 2010

Zhang ChiYu, Ding Na, Chen KePing, Yang RongGe

Abstract excerpt

HIV-1 co-receptor tropism is central for understanding the transmission and pathogenesis of HIV-1 infection. We performed a genome-wide comparison between the adaptive evolution of R5 and X4 variants from HIV-1 subtypes B and C. The results showed that R5 and X4 variants experienced differential evolutionary patterns and different HIV-1 genes encountered various positive selection pressures, suggesting that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20953943
DOI: 10.1007/s11427-010-4066-5
PMCID: PMC7089306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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