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Article

Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage.

Bioinformatics (Oxford, England) - 15 Feb 2013

Chen Mengjie, Svicher Valentina, Artese Anna, Costa Giosuè, Alteri Claudia, Ortuso Francesco, Parrotta Lucia, Liu Yang, Liu Chang, Perno Carlo Federico, Alcaro Stefano, Zhang Jing

Abstract excerpt

MOTIVATION: To define V3 genetic elements and structural features underlying different HIV-1 co-receptor usage in vivo. RESULTS: By probabilistically modeling mutations in the viruses isolated from HIV-1 B subtype patients, we present a unique statistical procedure that would first identify V3 determinants associated with the usage of different co-receptors cooperatively or independently, and then delineate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23297034
DOI: 10.1093/bioinformatics/btt002
PMCID: PMC3570207

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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