Article
Prediction of R5, X4, and R5X4 HIV-1 coreceptor usage with evolved neural networks.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Lamers Susanna L, Salemi Marco, McGrath Michael S, Fogel Gary B
Abstract excerpt
The HIV-1 genome is highly heterogeneous. This variation affords the virus a wide range of molecular properties, including the ability to infect cell types, such as macrophages and lymphocytes, expressing different chemokine receptors on the cell surface. In particular, R5 HIV-1 viruses use CCR5 as co-receptor for viral entry, X4 viruses use CXCR4, whereas some viral strains, known as R5X4 or D-tropic, have the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.