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Article

HIV-1 Tropism Determines Different Mutation Profiles in Proviral DNA.

PloS one - 1 Jan 2015

Nascimento-Brito Sieberth, Paulo Zukurov Jean, Maricato Juliana T, Volpini Angela C, Salim Anna Christina M, Araújo Flávio M G, Coimbra Roney S, Oliveira Guilherme C, Antoneli Fernando, Janini Luiz Mário R

Abstract excerpt

In order to establish new infections HIV-1 particles need to attach to receptors expressed on the cellular surface. HIV-1 particles interact with a cell membrane receptor known as CD4 and subsequently with another cell membrane molecule known as a co-receptor. Two major different co-receptors have been identified: C-C chemokine Receptor type 5 (CCR5) and C-X-C chemokine Receptor type 4 (CXCR4) Previous reports...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26413773
DOI: 10.1371/journal.pone.0139037
PMCID: PMC4587555

Genes

CCR5
CXCR4

Provenance

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