Article
On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition.
AIDS research and human retroviruses - 1 Aug 2016
Lamers Susanna L, Fogel Gary B, Liu Enoch S, Salemi Marco, McGrath Michael S
Abstract excerpt
HIV-1 enters immune cells via binding the viral envelope to a host cell CD4 receptor, and then a secondary co-receptor, usually CCR5 (R5) or CXCR4 (X4), and some HIV can utilize both co-receptors (R5X4). Although a small set of amino-acid properties such as charge and sequence length applied to HIV-1 envelope V3 loop sequence data can be used to predict co-receptor usage, we sought to expand the fundamental...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.