Article
Predicted co-receptor tropism and sequence characteristics of China HIV-1 V3 loops: implications for the future usage of CCR5 antagonists and AIDS vaccine development.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2009
Zhang Chiyu, Xu Shungao, Wei Jifu, Guo Hongxiong
Abstract excerpt
BACKGROUND: The co-receptor tropism of any given HIV-1 isolate is closely associated with the progression of AIDS. Understanding the co-receptor tropism and genetic diversity of circulating HIV-1 strains is critical for AIDS treatment and vaccine development. METHODS: All available China HIV-1 V3 sequences with known subtypes/circulating recombinant forms (CRFs) and transmission routes were retrieved from the Los...
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