Article
Identification of the BRD1 interaction network and its impact on mental disorder risk.
Genome medicine - 3 May 2016
Fryland Tue, Christensen Jane H, Pallesen Jonatan, Mattheisen Manuel, Palmfeldt Johan, Bak Mads, Grove Jakob, Demontis Ditte, Blechingberg Jenny, Ooi Hong Sain, Nyegaard Mette, Hauberg Mads E, Tommerup Niels, Gregersen Niels, Mors Ole, Corydon Thomas J, Nielsen Anders L, Børglum Anders D
Abstract excerpt
BACKGROUND: The bromodomain containing 1 (BRD1) gene has been implicated with transcriptional regulation, brain development, and susceptibility to schizophrenia and bipolar disorder. To advance the understanding of BRD1 and its role in mental disorders, we characterized the protein and chromatin interactions of the BRD1 isoforms, BRD1-S and BRD1-L. METHODS: Stable human cell lines expressing epitope tagged BRD1-S...
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