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Article

DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.

PloS one - 1 Jan 2017

Dyrvig Mads, Qvist Per, Lichota Jacek, Larsen Knud, Nyegaard Mette, Børglum Anders D, Christensen Jane H

Abstract excerpt

The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes. Genetic variants in the BRD1 locus show association with schizophrenia and bipolar disorder and risk alleles in the promoter region correlate with reduced BRD1 expression. Insights into the...

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Identifiers

PMID: 28095495
DOI: 10.1371/journal.pone.0170121
PMCID: PMC5240986

Genes

BRD1

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DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.PMID 28095495Read ↗

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