Article

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

2018-01-31

Abstract excerpt

The schizophrenia and bipolar disorder associated gene, BRD1 , encodes a scaffold protein that in complex with epigenetic modifiers regulate gene sets enriched for psychiatric disorder risk. Preclinical evidence from male Brd1 +/− mice has previously implicated BRD1 with phenotypes of translational relevance to schizophrenia. Here we describe the phenotype of female Brd1 +/− mice and report attenuated dendritic...

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Literature Corpus work: 4956a131-f5b9-5ba2-933f-bf9266e90a5f
DOI: 10.1101/257170

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