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Article

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression.

Cell reports - 10 May 2016

Thu Yee Mon, Van Riper Susan Kaye, Higgins LeeAnn, Zhang Tianji, Becker Jordan Robert, Markowski Todd William, Nguyen Hai Dang, Griffin Timothy Jon, Bielinsky Anja Katrin

Abstract excerpt

Loss of minichromosome maintenance protein 10 (Mcm10) causes replication stress. We uncovered that S. cerevisiae mcm10-1 mutants rely on the E3 SUMO ligase Mms21 and the SUMO-targeted ubiquitin ligase complex Slx5/8 for survival. Using quantitative mass spectrometry, we identified changes in the SUMO proteome of mcm10-1 mutants and revealed candidates regulated by Slx5/8. Such candidates included subunits of the...

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Identifiers

PMID: 27134171
DOI: 10.1016/j.celrep.2016.04.017
PMCID: PMC4864160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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