Article
Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.
PloS one - 1 Jan 2013
van de Pasch Loes A L, Miles Antony J, Nijenhuis Wilco, Brabers Nathalie A C H, van Leenen Dik, Lijnzaad Philip, Brown Markus K, Ouellet Jimmy, Barral Yves, Kops Geert J P L, Holstege Frank C P
Abstract excerpt
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of SUMO-targeted ubiquitin ligases (STUbLs). Slx5/8 has been implicated in genome stability and transcription, but the precise contribution is unclear. To characterise Slx5/8 function, we determined genome-wide changes in gene expression upon loss of either subunit. The majority of mRNA changes are part of a general...
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