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Article

Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication.

DNA repair - 4 Jun 2009

Ohuchi Takashi, Seki Masayuki, Kugou Kazuto, Tada Shusuke, Ohta Kunihiro, Enomoto Takemi

Abstract excerpt

Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA-damaging agents such as methyl methanesulfonate (MMS) or the DNA replication inhibitor hydroxyurea (HU). The kinase-defective mutant rad53-K227A also...

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Source

Identifiers

PMID: 19261547
DOI: 10.1016/j.dnarep.2009.01.018

Genes

RAD51

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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