Article
Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae.
DNA repair - 7 Mar 2006
Zhang Chaoying, Roberts Tania M, Yang Jay, Desai Ridhdhi, Brown Grant W
Abstract excerpt
Replication forks can stall spontaneously at specific sites in the genome, and upon encountering DNA lesions resulting from chemical or radiation damage. In Saccharomyces cerevisiae proteins implicated in processing of stalled replication forks include those encoded by the SGS1, TOP3, MUS81, MMS4, SLX1, SLX4, SLX5/HEX3, and SLX8 genes. We tested the roles of these genes in suppressing gross chromosomal...
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