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Article

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.

Genes & development - 15 Apr 2016

Horigome Chihiro, Bustard Denise E, Marcomini Isabella, Delgoshaie Neda, Tsai-Pflugfelder Monika, Cobb Jennifer A, Gasser Susan M

Abstract excerpt

High-resolution imaging shows that persistent DNA damage in budding yeast localizes in distinct perinuclear foci for repair. The signals that trigger DNA double-strand break (DSB) relocation or determine their destination are unknown. We show here that DSB relocation to the nuclear envelope depends on SUMOylation mediated by the E3 ligases Siz2 and Mms21. In G1, a polySUMOylation signal deposited coordinately by...

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Share to DNA Breaks, Double-Stranded
Share to Nuclear Envelope

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Saccharomyces cerevisiae Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 27056668
DOI: 10.1101/gad.277665.116
PMCID: PMC4840299

Genes

SMC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.PMID 27056668Read ↗

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