Article
Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C.
Scientific reports - 29 Apr 2016
Riemenschneider Mona, Cashin Kieran Y, Budeus Bettina, Sierra Saleta, Shirvani-Dastgerdi Elham, Bayanolhagh Saeed, Kaiser Rolf, Gorry Paul R, Heider Dominik
Abstract excerpt
Antiretroviral treatment of Human Immunodeficiency Virus type-1 (HIV-1) infections with CCR5-antagonists requires the co-receptor usage prediction of viral strains. Currently available tools are mostly designed based on subtype B strains and thus are in general not applicable to non-B subtypes. However, HIV-1 infections caused by subtype B only account for approximately 11% of infections worldwide. We evaluated...
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