Article
Comparison of two genotypic algorithms to determine HIV-1 tropism.
HIV medicine - 1 Jan 2008
Soulié C, Derache A, Aimé C, Marcelin A-G, Carcelain G, Simon A, Katlama C, Calvez V
Abstract excerpt
OBJECTIVES: One or both of two co-receptors, CCR5 (R5) and CXCR4 (X4), are used by HIV-1 to enter into host cells. The glycoprotein 120 (gp120) V3 sequence is correlated with the R5 and X4 phenotype. CCR5 inhibitors are specifically active against R5 viruses, suggesting the need to determine tropism before the use of these antagonists. A comparison of the position-specific scoring matrices (PSSM) and Geno2pheno...
Topics
- Adult
- Aged
- Algorithms
- CD4 Lymphocyte Count
- Female
- Genotype
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged
- Phenotype
- Polymerase Chain Reaction