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Article

Evaluation of genotypic tropism prediction tests compared with in vitro co-receptor usage in HIV-1 primary isolates of diverse subtypes.

The Journal of antimicrobial chemotherapy - 1 Jan 2012

Delgado Elena, Fernández-García Aurora, Vega Yolanda, Cuevas Teresa, Pinilla Milagros, García Valentina, Sánchez Mónica, González María, Sánchez Ana María, Thomson Michael M, Pérez-Álvarez Lucía

Abstract excerpt

OBJECTIVES: To evaluate the sensitivity and specificity of genotypic methods for predicting the co-receptor usage of subtypes B and non-B HIV-1 primary isolates, using as gold standard the infectivity of each primary isolate in GHOST cells stably expressing HIV-1 co-receptors. METHODS: Primary isolates were obtained by co-culturing either patient's peripheral blood mononuclear cells (PBMCs) or ultracentrifuged...

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PMID: 22010208
DOI: 10.1093/jac/dkr438

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