Article
Prediction of HIV type 1 subtype C tropism by genotypic algorithms built from subtype B viruses.
Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2010
Raymond Stéphanie, Delobel Pierre, Mavigner Maud, Ferradini Laurent, Cazabat Michelle, Souyris Corinne, Sandres-Sauné Karine, Pasquier Christophe, Marchou Bruno, Massip Patrice, Izopet Jacques
Abstract excerpt
BACKGROUND: Genotypic predictions of HIV-1 tropism could simplify CCR5 antagonist usage. However, the genotypic algorithms built from subtype B viruses could be inadequate for non-B subtypes. We therefore performed paired genotypic and phenotypic determination of subtype C tropism. METHODS: We studied 52 patients recruited in Malawi and 21 patients recruited in France. We directly sequenced the V3 env region and...
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