Article
Determination of co-receptor usage of HIV-1.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005
Schuitemaker Hanneke, Kootstra Neeltje A
Abstract excerpt
In addition to CD4, HIV-1 uses chemokine receptors for entry in their target cells. The most important chemokine receptors in this respect are beta-chemokine receptor 5 (CCR5) and alpha-chemokine receptor 4 (CXCR4). Coreceptor usage is an important feature of the biological phenotype of HIV-1 variants. In this chapter, methods are described to determine the co-receptor usage of HIV-1 variants.
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