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Article

Dysregulation of mprF and dltABCD expression among daptomycin-non-susceptible MRSA clinical isolates.

The Journal of antimicrobial chemotherapy - 1 Aug 2016

Bayer Arnold S, Mishra Nagendra N, Cheung Ambrose L, Rubio Aileen, Yang Soo-Jin

Abstract excerpt

BACKGROUND: In small series or individual reports, SNPs within the mprF ORF and dysregulation of its expression in Staphylococcus aureus have been linked to daptomycin resistance (DAP-R) via a proposed gain-in-function mechanism. Similarly, dysregulation of dltABCD has also been associated with DAP-R. METHODS: Using 22 well-characterized, isogenic daptomycin-susceptible (DAP-S)/DAP-R clinical MRSA strain pairs,...

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Identifiers

PMID: 27121398
DOI: 10.1093/jac/dkw142
PMCID: PMC4954926

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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