Article
VraSR two-component regulatory system contributes to mprF-mediated decreased susceptibility to daptomycin in in vivo-selected clinical strains of methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Jan 2012
Mehta Shrenik, Cuirolo Arabela X, Plata Konrad B, Riosa Sarah, Silverman Jared A, Rubio Aileen, Rosato Roberto R, Rosato Adriana E
Abstract excerpt
Daptomycin (DAP) is a new class of cyclic lipopeptide antibiotic highly active against methicillin-resistant Staphylococcus aureus (MRSA) infections. Proposed mechanisms involve disruption of the functional integrity of the bacterial membrane in a Ca-dependent manner. In the present work, we investigated the molecular basis of DAP resistance in a group of isogenic MRSA clinical strains obtained from patients with...
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