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Article

Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance.

Antimicrobial agents and chemotherapy - 1 Nov 2013

Yang Soo-Jin, Mishra Nagendra N, Rubio Aileen, Bayer Arnold S

Abstract excerpt

Single nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) have been commonly observed in daptomycin-resistant (DAP(r)) Staphylococcus aureus strains. Such SNPs are usually associated with a gain-in-function phenotype, in terms of either increased synthesis or enhanced translocation (flipping) of lysyl-phosphatidylglycerol (L-PG). However, it is unclear if such mprF SNPs are causal in DAP(r)...

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Identifiers

PMID: 24002096
DOI: 10.1128/AAC.01184-13
PMCID: PMC3811309

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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