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Article

Impact of Multiple Single-Nucleotide Polymorphisms Within mprF on Daptomycin Resistance in Staphylococcus aureus.

Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2018

Yang Soo-Jin, Mishra Nagendra N, Kang Kyoung-Mi, Lee Gi-Yong, Park Jong-Hwan, Bayer Arnold S

Abstract excerpt

A number of single nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) have been associated with daptomycin-resistance (DAP-R) in Staphylococcus aureus. Such SNPs have been found throughout the mprF ORF, although there are clearly preferred "hot spots" within this gene frequently linked to DAP-R phenotype. These mprF SNPs are often correlated with a gain-in-function phenotype, either in terms...

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Identifiers

PMID: 29381428
DOI: 10.1089/mdr.2017.0156
PMCID: PMC6200021

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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