Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of genetic changes associated with daptomycin nonsusceptibility in Staphylococcus aureus.

PloS one - 1 Jan 2018

Ma Zhuo, Lasek-Nesselquist Erica, Lu Jackson, Schneider Ryan, Shah Riddhi, Oliva George, Pata Janice, McDonough Kathleen, Pai Manjunath P, Rose Warren E, Sakoulas George, Malik Meenakshi

Abstract excerpt

The extensive use of daptomycin (DAP) for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the last decade has led to the emergence of DAP non-susceptible (DNS) Staphylococcus aureus strains. A better understanding of the molecular changes underlying DAP-non-susceptibility is required for early diagnosis and intervention with alternate combination therapies. The phenotypic changes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Daptomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Methicillin-Resistant Staphylococcus aureus

Share to Microbial Sensitivity Tests

Share to Staphylococcal Infections

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29879195
DOI: 10.1371/journal.pone.0198366
PMCID: PMC5991675

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of genetic changes associated with daptomycin nonsusceptibility in Staphylococcus aureus.PMID 29879195Read ↗

Down-regulation of the two-component system and cell-wall biosynthesis-related genes was associated with the reversion to daptomycin susceptibility in daptomycin non-susceptible methicillin-resistant Staphylococcus aureus.Semantic proximity Read ↗

dltA overexpression: A strain-independent keystone of daptomycin resistance in methicillin-resistant Staphylococcus aureus.Semantic proximity Read ↗

Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureusSemantic proximity Read ↗

Phenotypic and genotypic correlates of daptomycin-resistant methicillin-susceptible Staphylococcus aureus clinical isolates.Semantic proximity Read ↗

Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides.Semantic proximity Read ↗

Phenotypic and genetic characterization of daptomycin non-susceptible Staphylococcus aureus strains selected by adaptive laboratory evolution.Semantic proximity Read ↗

Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approachSemantic proximity Read ↗

Whole-genome sequencing identifies MprF mutations in a genetically diverse population of daptomycin non-susceptible Staphylococcus aureus in Australia.Semantic proximity Read ↗

Differential daptomycin resistance development in Staphylococcus aureus strains with active and mutated gra regulatory systems.Semantic proximity Read ↗

Daptomycin Resistant Staphylococcus aureus Clinical Strain With Novel Non-synonymous Mutations in the mprF and vraS Genes: A New Insight Into Daptomycin ResistanceSemantic proximity Read ↗

Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus.Semantic proximity Read ↗

Genetic profile of MRSA and MSSA clinical isolates with daptomycin MIC > 1 mg/LSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.