Article
Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides.
Antimicrobial agents and chemotherapy - 1 Dec 2014
Bayer Arnold S, Mishra Nagendra N, Sakoulas George, Nonejuie Poochit, Nast Cynthia C, Pogliano Joseph, Chen Kuan-Tsen, Ellison Steven N, Yeaman Michael R, Yang Soo-Jin
Abstract excerpt
Over the past several years, single-nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) have been proposed to be associated with a gain-of-function phenotype in terms of daptomycin (DAP) nonsusceptibility (referred to as daptomycin resistance [DAP-R] herein for ease of presen...
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