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Article

Impact of daptomycin resistance on Staphylococcus aureus virulence.

Virulence - 1 Jan 2015

Cameron David R, Mortin Lawrence I, Rubio Aileen, Mylonakis Eleftherios, Moellering Robert C, Eliopoulos George M, Peleg Anton Y

Abstract excerpt

Daptomycin resistance (DAP(R)) in Staphylococcus aureus is associated with mutations in genes that are also implicated in staphylococcal pathogenesis. Using a laboratory-derived series of DAP exposed strains, we showed a relationship between increasing DAP MIC and reduced virulence in a Galleria mellonella infection model. Point mutations in walK and rpoC led to cumulative reductions in virulence and simultaneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25830650
DOI: 10.1080/21505594.2015.1011532
PMCID: PMC4601193

Genes

DAP

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