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Article

NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing.

Oncotarget - 21 Jun 2016

Chang Pi-Yueh, Chen Jinn-Shiun, Chang Nai-Chung, Chang Shih-Cheng, Wang Mei-Chia, Tsai Shu-Hui, Wen Ying-Hao, Tsai Wen-Sy, Chan Err-Cheng, Lu Jang-Jih

Abstract excerpt

Colorectal cancer (CRC) arises from mutations in a subset of genes. We investigated the germline and somatic mutation spectrum of patients with CRC in Taiwan by using the AmpliSeq Cancer Hotspot Panel V2. Fifty paired freshly frozen stage 0-IV CRC tumors and adjacent normal tissue were collected. Blood DNA from 20 healthy donors were used for comparison of germline mutations. Variants were identified using an...

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Identifiers

PMID: 27121310
DOI: 10.18632/oncotarget.8885
PMCID: PMC5122332

Genes

APC
NRAS
CDH1
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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