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Mutation spectrum of germline cancer susceptibility genes among unselected Chinese colorectal cancer patients

1 Apr 2019

Abstract excerpt

Background: Genetic factors play an important role in colorectal cancer (CRC) risk, yet the prevalence and spectrum of germline cancer susceptibility gene mutations among unselected Chinese CRC patients is largely undetermined. Methods: We performed next-generation sequencing with a 73-genes panel and analyzed the prevalence and spectrum of germline mutations in 618 unselected Chinese CRC patients. We classified...

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PMID: 31118792
DOI: 10.2147/cmar.s193985

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