Association between germline variants and somatic mutations in colorectal cancer.

doi:10.1038/s41598-022-14408-2

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Association between germline variants and somatic mutations in colorectal cancer.

Scientific reports - 17 Jun 2022

Barfield Richard, Qu Conghui, Steinfelder Robert S, Zeng Chenjie, Harrison Tabitha A, Brezina Stefanie, Buchanan Daniel D, Campbell Peter T, Casey Graham, Gallinger Steven, Giannakis Marios, Gruber Stephen B, Gsur Andrea, Hsu Li, Huyghe Jeroen R, Moreno Victor, Newcomb Polly A, Ogino Shuji, Phipps Amanda I, Slattery Martha L, Thibodeau Stephen N, Trinh Quang M, Toland Amanda E, Hudson Thomas J, Sun Wei, Zaidi Syed H, Peters Ulrike

Abstract excerpt

Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better understand the impact of the host genome on somatically mutated genes and pathways, we assessed associations of germline variations with somatic events via two complementary approaches. We first analyzed the association between individual germline genetic...

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Identifiers

PMID: 35715570
DOI: 10.1038/s41598-022-14408-2
PMCID: PMC9205954

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