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Article

A de novo germline mutation of APC for inheritable colon cancer in a Chinese family using multigene next generation sequencing.

Biochemical and biophysical research communications - 9 May 2014

Zhang Yan, Lu Guanting, Hu Qingtao, Wang Xueyan, Li Chaohua, Mao Yuegan, Cui Manhua

Abstract excerpt

Inheritable colorectal cancers (CRC) accounted for about 20% of the CRC cases, such as hereditary nonpolyposis colorectal cancer (HNPCC), Gardner syndrome and familial adenomatous polyposis (FAP). A four-generation Han Chinese family was found affected with polyposis in colons. Inferred from the...

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Source

Identifiers

PMID: 24735542
DOI: 10.1016/j.bbrc.2014.04.014

Genes

APC
MSH2
FAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24735542-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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