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Article

A de novo germline mutation of APC for inheritable colon cancer in a Chinese family using multigene next generation sequencing.

Biochemical and biophysical research communications - 9 May 2014

Zhang Yan, Lu Guanting, Hu Qingtao, Wang Xueyan, Li Chaohua, Mao Yuegan, Cui Manhua

Abstract excerpt

Inheritable colorectal cancers (CRC) accounted for about 20% of the CRC cases, such as hereditary nonpolyposis colorectal cancer (HNPCC), Gardner syndrome and familial adenomatous polyposis (FAP). A four-generation Han Chinese family was found affected with polyposis in colons. Inferred from the pedigree structure, the disease in this family showed an autosomal dominant inheritance model. To locate the causal...

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Source

Identifiers

PMID: 24735542
DOI: 10.1016/j.bbrc.2014.04.014

Genes

APC
MSH2
FAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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