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Article

Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.

Oncotarget - 31 Jan 2017

Ashktorab Hassan, Mokarram Pooneh, Azimi Hamed, Olumi Hasti, Varma Sudhir, Nickerson Michael L, Brim Hassan

Abstract excerpt

PURPOSE: Next Generation Sequencing (NGS) is currently used to establish mutational profiles in many multigene diseases such as colorectal cancer (CRC), which is on the rise in many parts of the developing World including, Iran. Little is known about its genetic hallmarks in these populations. AIM: To identify variants in 15 CRC-associated genes in patients of Iranian descent. RESULTS: There were 51 validated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28002797
DOI: 10.18632/oncotarget.13977
PMCID: PMC5341754

Genes

APC
MSH3
MSH6
AMER1
BRAF
KRAS
SMAD4
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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