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Article

Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients.

World journal of gastroenterology - 21 Feb 2016

Chang Yuli Christine, Chang Jan-Gowth, Liu Ta-Chih, Lin Chien-Yu, Yang Shu-Fen, Ho Cheng-Mao, Chen William Tzu-Liang, Chang Ya-Sian

Abstract excerpt

AIM: To investigate the driver gene mutations associated with colorectal cancer (CRC) in the Taiwanese population. METHODS: In this study, 103 patients with CRC were evaluated. The samples consisted of 66 men and 37 women with a median age of 59 years and an age range of 26-86 years. We used high-resolution melting analysis (HRM) and direct DNA sequencing to characterize the mutations in 13 driver genes of...

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Identifiers

PMID: 26900293
DOI: 10.3748/wjg.v22.i7.2314
PMCID: PMC4735005

Genes

APC
MLH1
MSH2
PMS2
MSH6
MUTYH
SMAD4

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