Article
Genetic landscape of Chinese colorectal cancer: insights into germline and somatic mutations.
BMC cancer - 10 Mar 2026
Zhao Fazhi, Lin Hexin, Han Rui, Wang Meng, Yang Lin, Tian Dianfeng, Zhong Liangqi, Zhang Pengxin, Liu Queling
Abstract excerpt
BACKGROUND: Germline pathogenic alleles predispose carriers to malignancies; failure to recognize the underlying cancer susceptibility and subsequent delayed diagnosis may lead to severe health impairment. It remains largely undetermined what the somatic mutation characteristics are in colorectal cancer (CRC) patients with pathogenic/likely pathogenic (P/LP) germline mutations and whether, and how, these germline...
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