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Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large-Scale Genomic Analysis of 1094 Patients.

Cancer medicine - 1 Jun 2026

Lu Liting, Peng Xinyu, Zhang Jiaxin, Ding Yixin, Lu Junliang, Lin Hengxue, Wu Huanwen, Wang Xicheng, Ba Yi

Abstract excerpt

OBJECTIVE: To investigate the prevalence, characteristics, and clinical implications of germline mutations in a consecutive cohort of Chinese colorectal cancer (CRC) patients, providing insights that may inform population-specific genetic testing strategies. METHODS: A total of 1094 CRC patients from two centers were retrospectively analyzed using a 53-gene hereditary cancer panel. Germline variants were...

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PMID: 42204638
DOI: 10.1002/cam4.71848
PMCID: PMC13240524

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MUTYH

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