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Article

GIFT4 fusokine converts leukemic B cells into immune helper cells.

Journal of translational medicine - 27 Apr 2016

Deng Jiusheng, Pennati Andrea, Cohen Jonathon B, Wu Yuanqiang, Ng Spencer, Wu Jian Hui, Flowers Christopher R, Galipeau Jacques

Abstract excerpt

BACKGROUND: Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy, and is characterized by excessive expansion of monoclonal abnormal mature B cells and more regulatory immune properties of T cell compartment. Thus, developing novel strategies to enhance immune function merits further investigation as a possible therapy for CLL. METHODS: We generated a fusion cytokine (fusokine) arising from...

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Share to Antigen-Presenting Cells
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Interleukin-4

Share to Janus Kinases

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to STAT5 Transcription Factor

Share to T-Lymphocytes, Helper-Inducer

Source

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Identifiers

PMID: 27118475
DOI: 10.1186/s12967-016-0865-1
PMCID: PMC4847253

Genes

APC
JAK1
JAK2
JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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