Article

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

2023-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Elimination of drug-resistant leukemia stem cells (LSCs) represents a major challenge to achieve a cure in acute myeloid leukemia (AML). Although AML blasts generally retain high levels of surface CD38 (CD38 pos ), the presence of CD34 and lack of CD38 expression (CD34 pos CD38 neg ) are immunophenotypic features of both LSC-enriched AML blasts and normal hematopoietic stem cells (HSCs). We r...

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Literature Corpus work: 91528671-c96e-5f9c-968f-b5defe3e361c
DOI: 10.1101/2023.02.27.530273

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