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Article

Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups.

International journal of molecular sciences - 12 Dec 2019

Decker Sarah, Zwick Anabel, Khaja Saleem Shifa, Kissel Sandra, Rettig Andres, Aumann Konrad, Dierks Christine

Abstract excerpt

Preclinical drug development for human chronic lymphocytic leukemia (CLL) requires robust xenograft models recapitulating the entire spectrum of the disease, including all prognostic subgroups. Current CLL xenograft models are hampered by inefficient engraftment of good prognostic CLLs, overgrowth with co-transplanted T cells, and the need for allogeneic humanization or irradiation. Therefore, we aimed to...

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Identifiers

PMID: 31842407
DOI: 10.3390/ijms20246277
PMCID: PMC6940872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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