Article
GM-CSF and IL-4 Fusion Cytokine Induces B Cell-Dependent Hematopoietic Regeneration.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2017
Deng Jiusheng, Li Yanqiu, Pennati Andrea, Yuan Shala, Wu Jian Hui, Waller Edmund K, Galipeau Jacques
Abstract excerpt
Hematopoietic stem cells (HSCs) have the capacity to self-renew and differentiate into hematopoietic cells and have been utilized to replace diseased bone marrow for patients with cancers and blood disorders. Although remarkable progress has been made in developing new tools to manipulate HSCs for clinic use, there is still no effective method to expand HSCs in vivo for quick repopulation of hematopoietic cells...
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