Article

The CD19-4-1BBL antibody fusion protein unleashes the immune system against high-risk chronic lymphocytic leukemia

2026-07-15

Abstract excerpt

<h4>ABSTRACT</h4> CD19-4-1BBL is a bispecific antibody fusion protein that targets CD19 and costimulates 4-1BB on T cells and other immune cells. Its antitumor activity has been reported in B-cell non-Hodgkin lymphoma with emphasis on its T-cell mediated cytotoxic activity. Its effect on other 4-1BB expressing immune cells is unexplored. Here, we investigated the molecular mechanisms and the antileukemic effect o...

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Literature Corpus work: bad9450c-e9f5-52d5-9589-7dd83f3fda3f
DOI: 10.64898/2026.07.09.737515

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