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IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells

14 Aug 2024

Abstract excerpt

The interleukin-1 receptor accessory protein (IL1RAP) is highly expressed on acute myeloid leukemia (AML) bulk blasts and leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs), providing an opportunity to target and eliminate the disease, while sparing normal hematopoiesis. Herein, we report the activity of BIF002, a novel anti-IL1RAP/CD3 T cell engager (TCE) in AML. Antibodies to IL1RAP...

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PMID: 39143574
DOI: 10.1186/s13045-024-01586-x

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