Article

BAFF, but not APRIL, initiates Chronic Lymphocytic Leukemia by inducing tumor-promoting genes rather than cell survival.

2023-07-26

Abstract excerpt

<title>Abstract</title> Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults, characterized by the expansion of CD19+ CD5+ B cells. The origin of CLL remains debated, with one model suggesting that CLL cells carrying mutations in the variable regions of immunoglobulin are derived from post-germinal center B cells, whereas unmutated CLL cells originate from CD5+</s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47ebe338-4d35-5356-91b8-067f44efb68d
DOI: 10.21203/rs.3.rs-3183670/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BAFF, but not APRIL, initiates Chronic Lymphocytic Leukemia by inducing tumor-promoting genes rather than cell survival.DOI 10.21203/rs.3.rs-3183670/v1Read

Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.Semantic proximity Read

Cellular origin and pathophysiology of chronic lymphocytic leukemia.Semantic proximity Read

The CD19-4-1BBL antibody fusion protein unleashes the immune system against high-risk chronic lymphocytic leukemiaSemantic proximity Read

Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular sourceSemantic proximity Read

B-cell–specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasionSemantic proximity Read

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factorSemantic proximity Read

Animal models for chronic lymphocytic leukemiaSemantic proximity Read

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemiaSemantic proximity Read

Lessons learned from the Eµ-TCL1 mouse model of CLLSemantic proximity Read

Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6–deficient processSemantic proximity Read

Role of BAFF and APRIL in human B‐cell chronic lymphocytic leukaemiaSemantic proximity Read

CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemiaSemantic proximity Read